- Since his breakthrough performance in Una notte da leoni (2009), he regularly gets invitations for wedding parties, with the request to come dressed as his 'Hangover' character Alan Garner. He says that he has no intention of ever honoring such a request.
- Has appeared in 2 films that have been Oscar nominated for Best Picture: Tra le nuvole (2009) and Birdman o (L'imprevedibile virtù dell'ignoranza) (2014). Birdman won the Best Picture Oscar.
- Nephew of former U.S. Congressman Nick Galifainakis (NC) (1967-1973), who ran for the U.S. Senate against Jesse Helms in 1972.
- His paternal grandparents, Emmanuel "Mike" Galifianakis and Sophia Kastrinakis, were Greek immigrants, born in Heraklion, Crete, Greece. His mother's ancestry is Scottish, English, Welsh, French Huguenot, and Irish.
- Zach and his wife Quinn Lundberg are parents to sons. First born son September 7, 2013, second son born November 7, 2016.
- Wife Quinn Lundberg gave birth to their first child, a boy born on September 7, 2013,.
- In the late 90s before his career started, he went on a road trip to California from New York with two friends. 20 years later he still have the same car.
- Cousin of cartoonist Nick Galifianakis.
- Zach and his family divide his time in North Carolina and has a farm on Vancouver Island.
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