Biografia

Her favorite character that she played was Susan in Il patriota (2000).

The Harris County Institute of Forensic Sciences ruled that McCole's death was accidental. The "combined toxic effects of hydrocodone and difluoroethane with carisoprodol" were listed as the main cause of death. Difluoroethane is commonly found in computer duster aerosol spray cans and is sometimes used in huffing.

On July 19, 2014, McCole Bartusiak was found dead in her apartment behind her parents' Houston home. Her mother told CNN and the Associated Press that the actress was found by her boyfriend, sitting up in her bed; she began CPR on her daughter before paramedics arrived, who then worked "for 45 minutes" to no avail. Helen McCole Bartusiak said Skye "had been healthy and did not drink or do drugs", and had recently been suffering from epileptic seizures and that this likely played a role in her death.

Made her own purses, which she took to premieres and other events.

Owned a Charlie's Angels (2000) doll signed by her I ragazzi della mia vita (2001) co-star Drew Barrymore.